Salt · The Research Doorway
Research
The work begins in pharmacognosy: understanding natural materials, identifying botanical candidates, and evaluating evidence before making a therapeutic claim. Cannabis and endocannabinoid signaling are part of that wider method. Psychedelic research requires its own evidence, safety, ethical, and regulatory assessment; not every psychedelic is a botanical drug.
ORCID profile: https://orcid.org/0009-0003-6397-2149
The Scientific Pathway
From plant knowledge to regulated evidence.
Pharmacognosy
The study of medicines and potential drug leads from natural sources. It connects careful identification and characterization with research questions, while respecting the people and traditions that carry the knowledge.
Novel Botanical Drug Discovery
Identifying and characterizing botanical candidates for their therapeutic potential, with the rigor of drug discovery applied to whole-plant and multi-constituent systems.
FDA Botanical Drug Development Pathway
FDA's botanical drug development guidance describes evidence and quality considerations for botanical products investigated as drugs. A development framework is not FDA approval of a plant, formulation, researcher, or treatment. Read the FDA guidance.
Endocannabinoid System Modulation
The translational focus: how botanical constituents interact with the endogenous cannabinoid system, and what that means for clinical and public health practice.
Natural Psychedelic Medicine
Pharmacognosy can inform work on natural materials with psychedelic constituents. Isolated, synthetic, and complex natural products may follow different development routes. Evidence, patient safety, community consent, and reciprocity remain distinct obligations. NIDA's research overview.
Peer-Reviewed Publication
Cannabis education and practice.
Archives of Psychiatric Nursing · 2026
Lessons learned from an academic and clinical partnership to address barriers and facilitators of cannabis education and practice
Dr. Lakisha Jenkins-Samuels coauthored this qualitative study of barriers and facilitators of cannabis nursing education and practice. The publication concerns education and practice; it does not report results from KF-ECS-2025.
Research Protocol and Current Status
KF-ECS-2025
Endocannabinoid System Deficiency: A Comprehensive Study of General, Clinical, and Medically Authorized Adult and Pediatric Populations.
KF-ECS-2025 is the Kiona Foundation's protocol concerning endocannabinoid system deficiency across proposed adult and pediatric populations. Its materials include consent documents in English, Spanish, and Haitian Creole. Independent IRB reconstitution is required before the next submission. The Foundation is not announcing current approval, enrollment, recruitment, intervention, participant availability, or results. Read the Foundation's current research status.
- Study identifier: KF-ECS-2025
- OHRP Federalwide Assurance: FWA00034558
- IRB Organization: IORG0012116
- Consent languages: English, Spanish, Haitian Creole
Plain Language
Questions people ask.
What is pharmacognosy, and how does it differ from herbalism?
Pharmacognosy studies medicines and potential drug leads from natural sources. Herbalism and pharmacognosy can inform one another; a responsible account distinguishes traditional knowledge, material identity, experimental findings and clinical evidence rather than treating them as interchangeable.
What is the FDA Botanical Drug Development pathway?
It is FDA's guidance for developing a botanical product as a drug through the standard investigational and approval process. It holds whole-plant and multi-constituent medicines to a real standard of evidence, quality, and safety.
What is the endocannabinoid system, and what does ECS modulation mean?
The endocannabinoid system is a signaling network involved in regulating many of the body's processes. ECS modulation is the study of how botanical constituents interact with that system, and what that means for clinical and public health practice.
Is this Cannabis research?
Cannabis is one case study within a broader botanical methodology, not the identity of the work. The research is rooted in pharmacognosy and novel botanical drug discovery across many plants.
What is the KF-ECS-2025 study?
It is the Foundation's protocol on endocannabinoid system deficiency. Independent IRB reconstitution is required before the next submission. No current approval, enrollment, recruitment, intervention, participant availability, or results are announced. Prepared consent materials do not mean participation is currently open.
What is novel botanical drug discovery?
Botanical drug discovery identifies and characterizes candidates and preparations for investigation. Natural-source discovery can also involve isolated compounds. A complex botanical product and a highly purified or synthetic drug are not automatically the same regulatory category.
What is clinical endocannabinoid deficiency?
It is the hypothesis that the body can become under-resourced in endocannabinoid signaling, which may make certain conditions more likely or more severe. It is an active area of research, framed as a question to study rather than a settled diagnosis.
Can the endocannabinoid system be supported through nutrition?
Nutrition is part of the research conversation, not a demonstrated treatment for endocannabinoid deficiency or cancer. Hemp seed and hemp seed oil are food materials, distinct from CBD extracts. NCI's terminology overview distinguishes edible seed oil from cannabinoid extracts. The Living Materia Medica provides separate botanical teaching, not a cancer protocol.
Who is Dr. Lakisha Jenkins-Samuels?
Dr. Lakisha Jenkins-Samuels, Ph.D., RH (AHG), is a Traditional Naturopath, Clinical Herbalist, and research scientist. Her work focuses on pharmacognosy, botanical drug discovery, endocannabinoid system research, scientific consulting, public policy, education, and nonprofit leadership. She is Founder and President of the Kiona Foundation and Principal Investigator named in its prepared endocannabinoid research protocol. These roles do not establish current study approval or available treatment.
Is Dr. Lakisha® the same person as Dr. Lakisha Jenkins-Samuels?
Yes. Dr. Lakisha® is the federally registered mark and professional brand used by Dr. Lakisha Jenkins-Samuels, Ph.D., RH (AHG). She also appears publicly as Dr. Lakisha Jenkins. All three names refer to the same person.
How is the research made equitable?
The design aims to include the communities most affected, with prepared consent materials in English, Spanish, and Haitian Creole. Community participation, language access, independent review, and appropriate consent are requirements before research proceeds, not outcomes demonstrated by this page.
Does the research include psychedelics?
Dr. Lakisha®'s broader professional interests include psychedelic science, policy, and patient safety. Her community-steering role and FDA public-hearing record are separate from KF-ECS-2025. This page does not announce a Foundation psychedelic trial, participant access, or therapeutic results. See the FDA public record.
Does Dr. Lakisha® provide medical advice or treatment through this site?
No. Dr. Lakisha® does not provide individualized medical treatment or patient care through this website. Everything here is educational. Nothing on this site is medical advice, a diagnosis, or a promise of outcome.
A free open teaching
The Living Materia Medica, free.
A gift, given freely: an introduction to the endocannabinoid system, and five plants carried from the historical record to the modern chemistry. Join the list and it is yours, along with occasional notes from the research.
Why It Matters
The equity case sits at the center, not the margin.
Health, agricultural, and Indigenous equity are not an afterthought to the science. They are the reason for the standard. Evidence generated with the communities most affected, and held to a recognized regulatory bar, is how botanical medicine earns a permanent place in the systems that decide who gets care.
Public testimony
At the FDA public hearing
Watch my September 14 testimony on the potential future therapeutic use of psychedelic drugs, in the full official record.
Watch the testimony